Home Print this page Email this page Users Online: 129
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2013  |  Volume : 1  |  Issue : 1  |  Page : 14-19

Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives


Department of Pathology, College of Medicine, University of Dammam and King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia

Correspondence Address:
Mohamed A Shawarby
P. O. Box 2208, Al-Khobar 31952
Kingdom of Saudi Arabia
Login to access the Email id

DOI: 10.4103/1658-631X.112908

Rights and Permissions

Morphologically identical breast cancers can display divergent clinical outcomes and responses to therapy. This can predominantly be attributed to molecular class differences that exist amongst histologically similar cancer types. Consequently, molecular classification can be more powerful than histopathology as a predictive factor for the different treatments. This article reviews the molecular classification of breast cancer and emphasizes that ethnic variations may exist in molecular class prevalence patterns. It also highlights key insights into the currently defined molecular classes as provided by ongoing research on primary breast cancers using recent state-of-the-art technology. Such research is revealing that significant molecular heterogeneity may exist within the molecular classes themselves. More diverse ethnic variations may also be unraveled. The results of ongoing and upcoming research may provide more precise prognostic and predictive information about breast cancer and perhaps a breakthrough step toward "personaliziation" of breast cancer treatment. Forty-one relevant articles (2000-2012) extracted through PubMed and Google advanced searches and at our institute's library were utilized to prepare the article, along with results of published and ongoing research by the authors.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5713    
    Printed103    
    Emailed3    
    PDF Downloaded1009    
    Comments [Add]    

Recommend this journal