|Year : 2015 | Volume
| Issue : 1 | Page : 1
Abdulaziz A Al-Quorain
Department of Medicine, College of Medicine, University of Dammam, Dammam, Saudi Arabia
|Date of Web Publication||20-Jan-2015|
Abdulaziz A Al-Quorain
P.O. Box 40001, Al-Khobar 31952
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Al-Quorain AA. Nigella Sativa. Saudi J Med Med Sci 2015;3:1
Nigella sativa is a plant, common in South and Southwest Asia, Southern Europe, North Africa, Middle East and Saudi Arabia.  N. sativa is regarded as an important medicine for a variety of diseases.  Chemically, the black seed oil include various conjugated linoleic acids, namely thymoquinone, dithymoquinone, melantin, nigilline, tannin and others. 
The therapeutic activity of N. sativa is originated in the presence of thymoquinone. In large doses, nigilline is paralytic and melantin is toxic, requiring moderate use in spices and in folk medicine.  Various studies have shown that N. sativa has a wide spectrum of medicinal properties. A large number of experimental studies have been conducted on N. sativa seed all over the world. These studies proved that it can be used as antihypertensive,  antidiabetic,  antimicrobial, , anti-inflammatory, analgesic,  gastroprotective, antioxidant and other activities. 
Aqueous suspension of the black seed has been used for these studies. Most of these, particularly on the gastroprotective qualities of the seed were well-designed and reproducible. Investigators "have ruled-out any bias or errors in the results." 
In view of the wide spectrum of conditions that N. sativa has been proved to be effective, drug companies are expected to have interest in this seed. Multi-center trials could be sponsored by these companies to further study the potential of this seed. One would expect this folk medicine to evolve one day into a global remedy, especially for various chronic diseases.
In this issue of our Journal, Dr. Abdulla Bamosa reviews the black seed; its pharmacological properties, activities and its uses in the management of type II diabetes mellitus.
| References|| |
Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, et al.
A review on therapeutic potential of Nigella sativa
: A miracle herb. Asian Pac J Trop Biomed 2013;3:337-52.
Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa
L. seed. Int Immunopharmacol 2005;5:1749-70.
Al-Jasir MS. Chemical composition and microflora of black cumin (Nigella Sativa
L.) seeds in Saudi Arabia. Food Chem 1992;45:239-42.
Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA. Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa
, in mice and rats. J Ayub Med Coll Abbottabad 2008;20:25-7.
Zaoui A, Cherrah Y, Lacaille-Dubois MA, Settaf A, Amarouch H, Hassar M. Diuretic and hypotensive effects of Nigella sativa
in the spontaneously hypertensive rat. Therapie 2000;55:379-82.
Salama RH. Hypoglycemic effect of lipoic Acid, carnitine and Nigella sativa
in diabetic rat model. Int J Health Sci (Qassim) 2011;5:126-34.
Sokmen A, Jones BM, Erturk M. The in vitro
antibacterial activity of Turkish medicinal plants. J Ethnopharmacol 1999;67:79-86.
Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, et al.
Comparative study of Nigella Sativa
and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia. Saudi J Gastroenterol 2010;16:207-14.
Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res 2004;18:195-9.
Al Mofleh IA, Alhaider AA, Mossa JS, Al-Sohaibani MO, Al-Yahya MA, Rafatullah S, et al
. Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa
on necrotizing agents-induced gastric injury in experimental animals. Saudi J Gastroenterol 2008;14:128-34.
Tariq M. Nigella sativa seeds: Folklore treatment in modern day medicine. Saudi J Gastroenterol 2008;14:105-6.