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Year : 2021  |  Volume : 9  |  Issue : 3  |  Page : 267-270

Unusual presentation of lipofibromatosis-like neural tumor in an adult: A case report

1 Department of Public Health, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, USA
2 Department of Pathology, Medical College of Georgia, Augusta, Georgia, USA
3 College of Medicine, USA
4 Department of Orthopedics, Medical College of Georgia, Augusta University, Augusta, Georgia, USA
5 Department of Radiology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA

Correspondence Address:
Joseph White
1120 15th street, BAE1572, Medical College of Georgia, Augusta University, Augusta, Georgia 309012
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DOI: 10.4103/sjmms.sjmms_63_21

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Lipofibromatosis-like neural tumor (LPF-NT) is a rare variant of lipofibromatosis. Standard lipofibromatosis tumors show a predilection for the distal extremities of male children or young adults and are typically painless, slow-growing, subcutaneous or deep soft tissue masses. We present a case of a 50-year-old male with a slowly expanding, right foot mass. Physical examination revealed a painful, non-tender firm mass on the right medial foot. Magnetic imaging studies revealed a poorly defined soft tissue mass extending through subcutaneous tissue up to the dermis. Histologic examination revealed a spindle cell neoplasm. Immunohistochemistry showed co-expression of S100 protein, CD34 and TRK. In addition, the lesion was found to be positive for the LMNA-NTRK1 fusion by next-generation sequencing. These findings were supportive of a diagnosis of LPF-NT. At 3-month post-excision, the patient had no pain and repeat imaging indicated no evidence of tumor. The authors recommended including LPF-NT in the differential diagnosis of masses or lesions that are fibro-fatty tumors.

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