Home Print this page Email this page Users Online: 287
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2022  |  Volume : 10  |  Issue : 1  |  Page : 63-66

A rare case of xanthomatous meningioma

1 Department of Pathology, Nevsehir State Hospital, Nevsehir, Turkey
2 Department of Pathology, Izmir Katip Celebi University Ataturk Research and Training Hospital, Izmir, Turkey
3 Department of Radiology, Samandag State Hospital, Hatay, Turkey
4 Department of Neurosurgery, Izmir Katip Celebi University Ataturk Research and Training Hospital, Izmir, Turkey

Correspondence Address:
Sultan Deniz Altindag
Department of Pathology, Nevsehir State Hospital, 15 Temmuz Mahallesi, 148. Sokak No: 1 Merkez, Nevsehir
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/sjmms.sjmms_705_20

Rights and Permissions

Xanthomatous meningioma is an extremely rare subtype of metaplastic meningiomas with few cases reported in the literature. Histopathologically, it is composed of oval-shaped cells that have central nuclei and cytoplasm with lipid-filled vacuoles, resembling macrophages. Here, the authors present a case of xanthomatous meningioma and discuss the hypotheses related to its origin and the differential diagnosis. A 40-year-old woman presented with an increased headache complaint over the past month. A computed tomography scan revealed a heterogeneous mass on the right parietal lobe, following which a right craniotomy was done. Microscopic examination showed neoplastic meningothelial cells with whorl formation and areas of xanthomatous changes. Both meningothelial and xanthomatous cells were positive with vimentin, progesterone, and epithelial membrane antigen. CD68 and lysozyme were expressed only in the xanthomatous component, and there was no expression with periodic acid-Schiff (PAS) stain and PAS–diastase. As the diagnostic criteria of atypical meningioma were not observed, a diagnosis of xanthomatous meningioma, WHO grade I, was made. Owing to the characteristic xanthomatous changes, its differential diagnosis includes grade II clear cell meningioma, Rosai–Dorfman disease, and hemangioblastoma. To avoid misidentifying these cells as macrophages, a high degree of awareness of this unique subtype of meningioma is required.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded213    
    Comments [Add]    

Recommend this journal